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Hu, Yo, and Ri Antibodies with Reflex to Titers and Western Blot, CSF
Test Code90122
CPT Codes
86255 (x3)
Includes
Hu Antibody Screen with Reflex to Titer and Western Blot, CSF
Yo Antibody Screen with Reflex to Titer and Western Blot, CSF
Ri Antibody Screen with Reflex to Titer and Western Blot, CSF
If Hu Antibody Screen, IFA, CSF is Positive, then Hu Antibody, WB, CSF will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, WB, CSF is Positive, then Hu Antibody Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
If Yo Antibody Screen, IFA, CSF is Positive, then Yo Antibody, WB, CSF will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, WB, CSF is Positive, then Yo Antibody, Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
If Ri Antibody Screen, IFA, CSF is Positive, then Ri Antibody, WB, CSF will be performed at an additional charge (CPT codes: 84181).
If Ri Antibody, WB, CSF is Positive, then Ri Antibody, Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
Yo Antibody Screen with Reflex to Titer and Western Blot, CSF
Ri Antibody Screen with Reflex to Titer and Western Blot, CSF
If Hu Antibody Screen, IFA, CSF is Positive, then Hu Antibody, WB, CSF will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, WB, CSF is Positive, then Hu Antibody Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
If Yo Antibody Screen, IFA, CSF is Positive, then Yo Antibody, WB, CSF will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, WB, CSF is Positive, then Yo Antibody, Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
If Ri Antibody Screen, IFA, CSF is Positive, then Ri Antibody, WB, CSF will be performed at an additional charge (CPT codes: 84181).
If Ri Antibody, WB, CSF is Positive, then Ri Antibody, Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
Preferred Specimen
2.4 mL CSF
Patient Preparation
Overnight fasting is preferred
Minimum Volume
1.5 mL
Transport Container
Sterile screw-cap vial
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 8 hours
Refrigerated: 7 days
Frozen: 6 months
Refrigerated: 7 days
Frozen: 6 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature
Methodology
Immunofluorescence Assay (IFA)
FDA Status
This test was developed and its performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Performance characteristics refer to the analytical performance of the test.
Setup Schedule
Set up: Mon, Wed, Fri a.m.; Report available: 4 days
Clinical Significance
Hu anti-neuronal nuclear antibody (anti-Hu) is found in 5-10% of patients with small cell carcinoma of the lung. Purkinje cell (Yo) antibody is found in patients with paraneoplastic cerebellar degeneration and is associated with breast, ovarian, and other gynecologic cancers. Some patients with ovarian cancer have low titers of Yo antibodies in the absence of cerebellar degeneration. Anti-Hu antibodies are associated with paraneoplastic encephalomyelitis and sensory neuropathy. Anti-Ri antibody can be detected in patients with paraneoplastic opsoclonus/myoclonus syndrome. Neoplasms most often associated with anti-Ri include breast cancer, small cell lung cancer, and gynecological cancers.
