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Hu, Yo, and Ri Antibodies with Reflex to Titers and Western Blot
Test Code90138
CPT Codes
86255 (x3)
Includes
Hu Antibody Screen with Reflex to Titer and Western Blot
Yo Antibody Screen with Reflex to Titer and Western Blot
Ri Antibody Screen with Reflex to Titer and Western Blot
If Hu Antibody Screen, IFA is Positive, then Hu Antibody, WB will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, WB is Positive, then Hu Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
If Yo Antibody Screen, IFA is Positive, Yo Antibody, WB will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, WB is Positive, then Yo Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
If Ri Antibody Screen, IFA is Positive, then Ri Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181).
If Ri Antibody, Western Blot is Positive, then Ri Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
Yo Antibody Screen with Reflex to Titer and Western Blot
Ri Antibody Screen with Reflex to Titer and Western Blot
If Hu Antibody Screen, IFA is Positive, then Hu Antibody, WB will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, WB is Positive, then Hu Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
If Yo Antibody Screen, IFA is Positive, Yo Antibody, WB will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, WB is Positive, then Yo Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
If Ri Antibody Screen, IFA is Positive, then Ri Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181).
If Ri Antibody, Western Blot is Positive, then Ri Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
Preferred Specimen
1.5 mL serum
Patient Preparation
Overnight fasting is preferred
Minimum Volume
0.6 mL
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days
Refrigerated: 14 days
Frozen: 21 days
Methodology
Immunofluorescence Assay (IFA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon, Wed, Fri; Report Available: 3 days
Reference Range
See Laboratory Report
Clinical Significance
Hu anti-neuronal nuclear antibody (anti-Hu) is found in 5-10% of patients with small cell carcinoma of the lung. Purkinje cell (Yo) antibody is found in patients with paraneoplastic cerebellar degeneration and is associated with breast, ovarian, and other gynecologic cancers. Some patients with ovarian cancer have low titers of Yo antibodies in the absence of cerebellar degeneration. Anti-Hu antibodies are associated with paraneoplastic encephalomyelitis and sensory neuropathy. Anti-Ri antibody can be detected in patients with paraneoplastic opsoclonus/myoclonus syndrome. Neoplasms most often associated with anti-Ri include breast cancer, small cell lung cancer, and gynecological cancers.
