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ER/PR/HER2 with Reflex to HER2 FISH, Paraffin Block [10970Z]
Test Code109708
CPT Codes
88360 (x3)
Includes
This test may reflex to HER2, FISH.
Preferred Specimen
1 formalin-fixed, paraffin-embedded tumor tissue block submitted in an IHC specimen transport kit
Other Acceptable Specimens
9 unstained (4-micron) sections, positively charged tissue on Poly-L-Lysine or Silane coated slides
Instructions
Tumor paraffin block (formalin-fixed only) or nine 4-micron unstained sections on Poly-L-Lysine or Silane coated slides.
See Specimen Collection Section, Oncology.
Please submit stained H & E slide and a copy of the pathology report. Ship at room temperature.
Invasive or metastatic breast cancer formalin fixed paraffin embedded or charged/+slides from formalin fixed paraffin embedded tissue. Specimen MUST be fixed in 10% neutral buffered formalin. Fixation between 6 and 72 hours is recommended. Pathology report must accompany paraffin block or slides. Information required in this report include: Physician identification, specimen identifiers (case and block number), specimen site and type, tissue processing used (routine or microwave), type of fixative, time and duration of fixation, pathologic diagnosis, and IHC score, if performed elsewhere. Ship at room temperature. Do not freeze.
See Specimen Collection Section, Oncology.
Please submit stained H & E slide and a copy of the pathology report. Ship at room temperature.
Invasive or metastatic breast cancer formalin fixed paraffin embedded or charged/+slides from formalin fixed paraffin embedded tissue. Specimen MUST be fixed in 10% neutral buffered formalin. Fixation between 6 and 72 hours is recommended. Pathology report must accompany paraffin block or slides. Information required in this report include: Physician identification, specimen identifiers (case and block number), specimen site and type, tissue processing used (routine or microwave), type of fixative, time and duration of fixation, pathologic diagnosis, and IHC score, if performed elsewhere. Ship at room temperature. Do not freeze.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Methodology
Immunohistochemistry (IHC)
Setup Schedule
Set up: Mon-Fri; Report available: 2 days
Reference Range
See Laboratory Report
Clinical Significance
Estrogen and progesterone receptor assays are routinely performed on breast carcinomas to assess reponsiveness to endocrine therapy and prognosis. HER-2 is associated with cellular proliferation activity. Overexpression is observed in 25-30% of women with breast cancer.
