Epstein-Barr Virus Antibody Panel

Test Code

6421

CPT Codes
86664, 86665 (x2)

Includes

Epstein-Barr Virus VCA Antibody (IgM), Epstein-Barr Virus VCA Antibody (IgG), Epstein-Barr Virus Nuclear Antigen (EBNA) Antibody (IgG)

Preferred Specimen

1 mL serum

Minimum Volume

0.8 mL

Transport Container

Plastic screw-cap vial

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days

Methodology
Immunoassay (IA)

Setup Schedule

Set up: Tues-Sat a.m.; Report available: Next day

Reference Range

Epstein-Barr Virus VCA Antibody (IgM)

U/mL	Interpretation
<36.00	Negative
36.00-43.99	Equivocal
>43.99	Positive

Epstein-Barr Virus VCA Antibody (IgG)

U/mL	Interpretation
<18.00	Negative
18.00-21.99	Equivocal
>21.99	Positive

Epstein-Barr Virus Nuclear Antigen (EBNA) Antibody (IgG)

U/mL	Interpretation
<18.00	Negative
18.00-21.99	Equivocal
>21.99	Positive

Clinical Significance

Primary infection by EBV causes infectious mononucleosis, usually a self-limiting disease in children and young adults. Infection with EBV can cause lymphoproliferative disorders including tumors. VCA-IgM is typically detectable at clinical presentation, then declines to undetectable levels within a month in young children and within 3 months in other individuals. VCA-IgG is typically detectable at clinical presentation, and persists for life. EBNA IgG typically appears during convalescence (3-4 months after clinical presentation) and remains detectable for life.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.