A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

DOG1, IHC without Interpretation

Test Code
90211


CPT Codes
88342

Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block


Other Acceptable Specimens
Minimum: 3 unstained, positively (+) charged slides


Transport Container
IHC Specimen Transport Kit


Transport Temperature
Room temperature


Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable


Methodology
Immunohistochemistry

Setup Schedule
Set up: Mon-Fri; Report available: Next day


Clinical Significance
DOG1 antibodies detect anoctamin 1, a marker of gastrointestinal stromal tumors that may be more sensitive (85-90% immunoreactive) than c-KIT antibodies (approximately 75%) or CD34 (approximately 70%), especially in the PDGFRA-mutated subgroup of GISTs. It is especially useful in the differential diagnosis with leiomyosarcoma and synovial sarcomas, which are nearly always negative for DOG1.




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.