Creatinine Clearance

Test Code

7943

CPT Codes
82575

Includes

Creatinine (serum and urine), Creatinine Clearance (calculation), eGFR

CPT code 81050 may be added at an additional charge for volume measurement

Preferred Specimen

1 mL serum spun and 10 mL of a well-mixed 24 hour unpreserved urine collected in a 24 hour urine container

Minimum Volume

0.5 mL

Other Acceptable Specimens

10 mL of a 24-hour urine collection in a urinalysis transport tube (yellow-top, blue fill line, preservative tube) • 1 mL plasma collected in a sodium heparin (green-top) tube, lithium heparin (green-top) tube, or spun PST tube

Instructions

Both serum and urine specimens must be submitted simultaneously for analysis.
⁠⁠⁠⁠⁠⁠⁠
Note: A serum creatinine level must be collected within 24 hours of the beginning or ending of the urine collection.
Please specify the total 24-hour urine volume on the request form.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Grossly icteric • Anticoagulants other than heparin

Methodology
Spectrophotometry (SP)

Setup Schedule

Set up: Daily; Report available: 1 day

Reference Range

Creatinine
Age	Male (mg/dL)	Female (mg/dL)
≤2 days	0.79-1.58	0.79-1.58
3-27 days	0.35-1.23	0.35-1.23
1 month-9 years	0.20-0.73	0.20-0.73
10-12 years	0.30-0.78	0.30-0.78
13-15 years	0.40-1.05	0.40-1.00
16-17 years	0.60-1.20	0.50-1.00
18-29 years	0.60-1.24	0.50-0.96
30-39 years	0.60-1.26	0.50-0.97
40-49 years	0.60-1.29	0.50-0.99
50-59 years	0.70-1.30	0.50-1.03
60-69 years	0.70-1.35	0.50-1.05
70-79 years	0.70-1.28	0.60-1.00
≥80 years	0.70-1.22	0.60-0.95

For patients >49 years of age, the upper reference limit for creatinine is approximately 13% higher for people identified as African-American.

eGFR

≥60 mL/min/1.73m²

Creatinine, 24-Hour Urine
<3 Years	Not established
3-8 Years	0.10-0.80 g/24 h
9-12 Years	0.20-1.40 g/24 h
13-17 Years	0.40-1.90 g/24 h
>17 Years	0.50-2.15 g/24 h

Creatinine Clearance, Urine
Male	85-125 mL/min
Female	75-115 mL/min

Clinical Significance

Creatinine Clearance is used to evaluate the glomerular filtration rate (GFR). Clearance is defined as that volume of plasma from which a measured amount of substance could be completely eliminated into the urine per unit of time. Daily creatinine production is fairly constant except when there is massive injury to muscle.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.