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C-Peptide
Test Code372
CPT Codes
84681
Preferred Specimen
1 mL serum
Patient Preparation
Patients should fast 12 hours prior to collection.
Minimum Volume
0.5 mL
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 4 days
Refrigerated: 7 days
Frozen: 7 days
Refrigerated: 7 days
Frozen: 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Plasma • Gross hemolysis
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Mon-Sat a.m.; Report available: Next day
Reference Range
0.80-3.85 ng/mL
Clinical Significance
C-Peptide is useful in the evaluation of pancreatic beta cell function (e.g., helping distinguish type 1 from type 2 diabetes mellitus, or monitoring patients who have received islet cell or pancreatic transplants) and for determining the source of insulin in patients with hyperinsulinemic hypoglycemia (e.g., distinguishing insulin-secreting tumors from exogenous insulin administration). It is also sometimes measured as an additional means (more resistant to hemolysis than is insulin itself) for evaluating glucose tolerance tests.