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Chromosome Analysis, Tissue
Test Code14593
CPT Codes
88233, 88262
Physician Attestation of Informed Consent
This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.
Preferred Specimen
5 x 5 mm tissue collected in a sterile container in Hanks', Ringer's solution or culture medium with antibiotics
Minimum Volume
2 x 3 mm
Other Acceptable Specimens
Tissue collected in sterile saline, in a sterile leak-proof container
Instructions
Patient clinical history/reason for referral required with test order.
See Genetics Specimen Collection Section for detailed specimen instructions.
Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination. Do not freeze. Do not reject.
See Genetics Specimen Collection Section for detailed specimen instructions.
Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination. Do not freeze. Do not reject.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable
Refrigerated: Acceptable
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Formalin-fixed
Methodology
Karyotype • Microscopy • Tissue Culture
Setup Schedule
Set up: Daily; Report available: 15 days
Reference Range
See Laboratory Report
Clinical Significance
Chromosome analysis of products of conception (POC) can detect fetal chromosome abnormalities, which are associated with approximately one-half of all first trimester spontaneous abortions. Chromosome testing on fibroblasts obtained from a tissue biopsy is performed to investigate tissue specific mosaicism not present in blood lymphocytes. Fresh cells from tissue biopsies obtained postmortem may still be suitable for chromosome analysis when the patient's blood is not available or viable. If chromosome analysis is unsuccessful, please contact the laboratory genetic counselor at 1-866-GENEINFO (1-866-436-3463) to discuss the option of adding chromosomal microarray (CMA) testing.
