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Chromosome Analysis, CLL/LPD
Test Code14601
CPT Codes
88237, 88264
Preferred Specimen
10 mL whole blood or 3 mL bone marrow collected in sodium heparin (green-top) tube
Minimum Volume
5 mL whole blood • 1 mL bone marrow
Other Acceptable Specimens
Whole blood or bone marrow collected in: sodium heparin (royal blue-top) tube, or sodium heparin lead-free (tan-top) tube
Instructions
Clinical history and reason for referral are required with test order. Prior bone marrow transplant or therapy information should be provided with test order.
Bone marrow 1-3 mL or whole blood 5-10 mL with lymphocytosis in a sodium heparin (green-top) tube. Bone marrow transport medium is available upon request.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
This test may be replaced by the following: Tissue Culture for Hematologic Disorder code; or with a Cytogenetics Communication, if a communication is required.
Bone marrow 1-3 mL or whole blood 5-10 mL with lymphocytosis in a sodium heparin (green-top) tube. Bone marrow transport medium is available upon request.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
This test may be replaced by the following: Tissue Culture for Hematologic Disorder code; or with a Cytogenetics Communication, if a communication is required.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: See instructions
Refrigerated: See instructions
Frozen: See instructions
Refrigerated: See instructions
Frozen: See instructions
Methodology
Culture • Karyotype • Microscopy
Setup Schedule
Set up: Mon-Sat; Report available: 8 days
Reference Range
See Laboratory Report
Clinical Significance
This test is used to perform cytogenetic analysis of bone marrow or blood from patients suspected of having a lymphoproliferative disorder (LPD) such as chronic lymphocytic leukemia (CLL).
Mitotically active cells from unstimulated and/or stimulated short-term cultures are studied. Special mitogens are used to stimulate B-cells, unless a T-cell disorder is specified. When available, 20 or more G-banded metaphases are analyzed microscopically.
Mitotically active cells from unstimulated and/or stimulated short-term cultures are studied. Special mitogens are used to stimulate B-cells, unless a T-cell disorder is specified. When available, 20 or more G-banded metaphases are analyzed microscopically.
