Chromosome Analysis, Amniotic Fluid

Test Code

14590

CPT Codes
88235, 88269, 88280

Physician Attestation of Informed Consent

This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.

Preferred Specimen

20 mL amniotic fluid collected in a sterile, screw-cap container, or nontoxic centrifuge tubes

Minimum Volume

5 mL

Instructions

30 mL is preferred if other testing, e.g., microarray, FISH, is ordered.

Ship at room temperature. Do not freeze.
Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab).

Note: Patient's age gestational age, and indication(s) for testing are necessary; please submit completed cytogenetics requisition form with information. Do not split even if AFP requested. Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab). Signed informed consent is a requirement. Amniotic fluid kit and handling instruction available upon request.

Please contact the laboratory Genetic Counselor at 1-866-GENEINFO (1-866-436-3463) with any questions.

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable

Methodology
Culture • Karyotype • Microscopy

Setup Schedule

Set up: Mon-Sat; Report available: 9-12 days

Reference Range

Interpretive report

Clinical Significance

This test will detect chromosome abnormalities of the fetus including numerical, structural, and mosaic abnormalities. Chromosome analysis will also reveal fetal sex and sex chromosome abnormalities. Indications for prenatal chromosome analysis may include advanced maternal age, abnormal fetal ultrasound, abnormal maternal serum screen, abnormal cell-free DNA results, history of a previous child with a chromosome abnormality, or a parent who carries a balanced chromosomal rearrangement or has another chromosome abnormality.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.