Celiac Disease Comprehensive Panel, Infant [15981X]

Test Code

15981

CPT Codes
86364, 86258, 82784

Includes

Tissue Transglutaminase (tTG) Antibody (IgA)
IgA (Immunoglobulin A)
Gliadin (Deamidated) Antibody (IgA)

If Tissue Transglutaminase (tTG) Antibody (IgA) is Detected (≥15.0 U/mL), then Endomysial Antibody Screen (IgA) will be performed at an additional charge (CPT code(s): 86231).
If the Endomysial Antibody Screen (IgA) is Positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).

If Immunoglobulin A is less than the lower limit of the reference range, based on age, then Transglutaminase (tTG) Antibody (IgG) will be performed at an additional charge (CPT code(s): 86364).

Preferred Specimen

5 mL serum

Minimum Volume

1.1 mL

Instructions

Note: Specimens from children less than 4 years of age (i.e., less than 48 months) are appropriate for this test. The test for people 4 years of age and older is the Celiac Disease Comprehensive Panel (Test Code 19955).

Transport Container

Plastic screw-cap vial

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 72 hours
Refrigerated: 7 days
Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly lipemic

Methodology
See individual tests

Setup Schedule

Set up: Mon-Fri; Report available: Next day

Reference Range

Tissue Transglutaminase (tTG) Antibody (IgA)

<15.0 U/mL		Antibody not detected
≥15.0 U/mL		Antibody detected

Gliadin (Deamidated) Antibody (IgA)

<15.0 U/mL		Antibody not detected
≥15.0 U/mL		Antibody detected

IgA (Immunoglobulin A)

Cord Blood

1-3 mg/dL

1-28 days

2-40 mg/dL

1-3 months

3-40 mg/dL

4-6 months

7-47 mg/dL

7-11 months

12-53 mg/dL

1 year

20-73 mg/dL

2 years

20-99 mg/dL

3-5 years

22-140 mg/dL

6-8 years

31-180 mg/dL

9-11 years

33-200 mg/dL

12-16 years

36-220 mg/dL

17-60 years

47-310 mg/dL

≥61 years

70-320 mg/dL

Clinical Significance

Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.
Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.
The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.