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CDX2, IHC with Interpretation
Test Code90153
CPT Codes
88342
Preferred Specimen
Formalin-fixed paraffin embedded tissue
Other Acceptable Specimens
Minimum: 3 unstained, positively charged slides
Instructions
Please include surgical pathology report.
Transport Container
IHC Specimen Transport Kit
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen
Methodology
Immunohistochemistry
Setup Schedule
Set up: Mon-Fri Morning; Report available: 3 days
Reference Range
See Laboratory Report
Clinical Significance
CDX-2, a nuclear transcription factor that is expressed in colonic epithelium, is useful in distinguishing metastatic carcinoma of colorectal origin from other tumors. However, its expression may be lost in advanced colorectal tumors and is also expressed by some mucinous tumors of other sites.