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CAH Panel 6 (StAR Deficiency)
Test Code15276
CPT Codes
82088, 82533, 82626, 84140
Includes
Cortisol, Total, LC/MS
Pregnenolone, LC/MS
DHEA (Dehydroepiandrosterone) Unconjugated
Aldosterone, LC/MS
Pregnenolone, LC/MS
DHEA (Dehydroepiandrosterone) Unconjugated
Aldosterone, LC/MS
Preferred Specimen
4 mL serum collected in a red-top tube (no gel)
Minimum Volume
1.6 mL
Instructions
Collect blood in a vacutainer with no additives. Allow blood to clot (30 minutes) at room temperature, 18°C to 25°C. Centrifuge and separate the serum from the cells. Freeze as soon as possible. Specify age and sex on test request form. Immediately put sample on ice after collection.
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 72 hours
Frozen -20° C: 14 days
Frozen -70° C: 30 days
Refrigerated: 72 hours
Frozen -20° C: 14 days
Frozen -70° C: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube (SST) • Moderate to gross hemolysis • Plasma
Methodology
Chromatography/Mass Spectrometry
Setup Schedule
Set up and Report available: See individual assays
Reference Range
See Laboratory Report
Clinical Significance
Steroidogenic acute regulatory protein (StAR) catalyzes the initial rate-limiting in the formation of steroid hormones. Affected individuals present with deficiency of cortisol and aldosterone, as well as early precursors in the synthesis of steroid hormones (Pregnenalone; DHEA (Dehydroepiandrosterone). Additional testing may be required to establish a diagnosis.
