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C4d, IHC without Interpretation
Test Code90196
CPT Codes
88342
Preferred Specimen
1 formalin-fixed, paraffin-embedded block, submitted in IHC Specimen Transport Kit
Other Acceptable Specimens
3 unstained, positively charged slides IHC Specimen Transport Kit; Room temperature
Instructions
Please include surgical pathology report.
Transport Container
IHC Specimen Transport Kit
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Do Not Freeze
Refrigerated: Indefinitely
Frozen: Do Not Freeze
Methodology
Immunohistochemistry
Setup Schedule
Setup: Mon-Fri morning; Report available: Next day
Clinical Significance
C4d, a stable split product of classical complement
activation, is a marker of antibody-mediated acute
allograft rejection as well as hyperacute rejection,
acute vascular rejection, acute cellular rejection, and
borderline rejection. Detection of C4d has been used
diagnostically as a predictor of transplant kidney graft
survival and for managing acute rejection.
activation, is a marker of antibody-mediated acute
allograft rejection as well as hyperacute rejection,
acute vascular rejection, acute cellular rejection, and
borderline rejection. Detection of C4d has been used
diagnostically as a predictor of transplant kidney graft
survival and for managing acute rejection.
