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C4d, IHC with Interpretation
Test Code90146
CPT Codes
88342
Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block
Other Acceptable Specimens
Minimum 3 unstained, positively charged slides
Instructions
Please include surgical pathology report.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Methodology
Immunohistochemistry
Setup Schedule
Set up: Mon-Fri; Report available: 3 days
Reference Range
Interpretive report
Clinical Significance
C4d, a stable split product of classical complement activation, is a marker of antibody-mediated acute allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. Detection of C4d has been used diagnostically as a predictor of transplant kidney graft survival for managing acute rejection.