C4d, IHC with Interpretation

Test Code
90146


CPT Codes
88342

Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block


Other Acceptable Specimens
Minimum 3 unstained, positively charged slides


Instructions
Please include surgical pathology report.


Transport Temperature
Room temperature


Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable


Methodology
Immunohistochemistry

Setup Schedule
Set up: Mon-Fri; Report available: 3 days


Reference Range
Interpretive report


Clinical Significance
C4d, a stable split product of classical complement activation, is a marker of antibody-mediated acute allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. Detection of C4d has been used diagnostically as a predictor of transplant kidney graft survival for managing acute rejection.




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.