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Borrelia Species DNA, Real-Time PCR, with Reflexes, Synovial Fluid/CSF
Test Code39218
CPT Codes
87801
Includes
If Borrelia Species DNA, Real-Time PCR is Detected, then Borrelia burgdorferi DNA, Qualitative Real-Time PCR, Miscellaneous and Borrelia miyamotoi DNA, Real-Time PCR, Miscellaneous will be performed at an additional charge (CPT Code(s): 87476, 87478)
Preferred Specimen
3 mL CSF or synovial fluid collected in a sterile plastic leak-proof container
Minimum Volume
0.5 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 30 days
Refrigerated: 7 days
Frozen: 30 days
Methodology
Real-Time Polymerase Chain Reaction
Setup Schedule
Set up: Mon-Sat; Report available: 2-3 days
Reference Range
Not detected
Clinical Significance
The diagnosis of Borreliosis is most often made by clinical examination combined with evidence of tick bite or exposure in endemic areas. Amplification of Borrelia genomic DNA from blood, fluids or tissues can support the diagnosis. This test detects Borrelia species which are associated with either Lyme disease (Borrelia burgdorferi), or relapsing fever (Borrelia miyamotoi).
A positive result for Borrelia species but negative result for Borrelia burgdorferi and Borrelia miyamotoi, may indicate that infection is caused by other Borrelia species. A negative result for Borrelia species does not rule out Borrelia infection and appropriate serology testing may be clinically warranted.
A positive result for Borrelia species but negative result for Borrelia burgdorferi and Borrelia miyamotoi, may indicate that infection is caused by other Borrelia species. A negative result for Borrelia species does not rule out Borrelia infection and appropriate serology testing may be clinically warranted.
