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Mantle Cell Lymphoma, bcl-1/JH, t(11;14), Cell-Based
Test Code14991
CPT Codes
81168<br />
Preferred Specimen
5 mL bone marrow or whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
1 mL
Other Acceptable Specimens
Formalin-fixed, paraffin-embedded tissue block
Transport Temperature
Room temperature
Specimen Stability
Bone marrow and whole blood:
Room temperature: 7 days
Refrigerated: 14 days
Frozen: Unacceptable
Tissue block:
Room temperature: Indefinitely
Refrigerated: Unacceptable
Frozen: Unacceptable
Room temperature: 7 days
Refrigerated: 14 days
Frozen: Unacceptable
Tissue block:
Room temperature: Indefinitely
Refrigerated: Unacceptable
Frozen: Unacceptable
Methodology
Real-Time Polymerase Chain Reaction (RT-PCR)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Tues, Sat; Report available: 3 days
Reference Range
0/Negative
Clinical Significance
Bcl-1/JH t(11;14) is highly specific for mantle cell lymphoma (MCL). The t(11;14) can be found in approximately 70% to 95% cases of MCL. Half of these translocations fall within the BCL-1 major translocation cluster (MTC). The t(11;14) Real-Time PCR assay can be used to monitor minimal residual disease in NHL. Ideally, recent patient samples should be tested side by side with the previous sample to better illustrate the quantitative changes.