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Celiac Disease Comprehensive Panel
Test Code94366
CPT Codes
82784, 83516 (x2), 86255, 86256<br /> Restricted Client Code
Includes
8821 Tissue Transglutaminase (tTG) Antibody (IgA)
539 Immunoglobulin A
If Tissue Transglutaminase (tTG) Antibody (IgA) is Detected (≥15.0 U/mL), then Endomysial Antibody (IgA) Screen with Reflex to Titer will be performed at an additional charge (CPT code(s): 86255).
If the Endomysial Antibody Screen (IgA) is Positive, then the Endomysial Antibody Titer will be performed at an additional charge (CPT code: 86256).
If Immunoglobulin A is less than the lower limit of the reference range, based on age, then Tissue Transglutaminase (tTG) Antibody (IgG) will be performed at an additional charge (CPT code(s): 83516).
539 Immunoglobulin A
If Tissue Transglutaminase (tTG) Antibody (IgA) is Detected (≥15.0 U/mL), then Endomysial Antibody (IgA) Screen with Reflex to Titer will be performed at an additional charge (CPT code(s): 86255).
If the Endomysial Antibody Screen (IgA) is Positive, then the Endomysial Antibody Titer will be performed at an additional charge (CPT code: 86256).
If Immunoglobulin A is less than the lower limit of the reference range, based on age, then Tissue Transglutaminase (tTG) Antibody (IgG) will be performed at an additional charge (CPT code(s): 83516).
Preferred Specimen
5 mL serum
Minimum Volume
1 mL
Instructions
Note: This panel is for patients who are > 3 years old.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 72 hours
Refrigerated: 7 days
Frozen: 21 days
Refrigerated: 7 days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic
Methodology
Immunoassay • Immunoturbidimetric
Setup Schedule
Set up: Tues-Sat; Report available: 1-4 days
Reference Range
See Laboratory Report
Clinical Significance
Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy. Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance. The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.
