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Autoimmune Rapidly Progressive Dementia Evaluation with Recombx®
Test Code93934
CPT Codes
83519, 83520 (x3), 86255 (x3), 86341<br /> **Restricted Client Use**
Includes
Recombx Hu Autoantibody Test (Autoimmune Rapidly Progressive Dementia)
Recombx MaTa Autoantibody Test (Autoimmune Rapidly Progressive Dementia)
Recombx CV2 Autoantibody Test (Autoimmune Rapidly Progressive Dementia)
Amphiphysin Antibody Test (Autoimmune Rapidly Progressive Dementia)
GAD65 Autoantibody Test (Autoimmune Rapidly Progressive Dementia)
NMDA Receptor Autoantibody Test (Autoimmune Rapidly Progressive Dementia)
VGKC Autoantibody Test (Autoimmune Rapidly Progressive Dementia)
LGI1 Autoantibody Test (Autoimmune Rapidly Progressive Dementia)
CASPR2 Autoantibody Test (Autoimmune Rapidly Progressive Dementia)
Recombx MaTa Autoantibody Test (Autoimmune Rapidly Progressive Dementia)
Recombx CV2 Autoantibody Test (Autoimmune Rapidly Progressive Dementia)
Amphiphysin Antibody Test (Autoimmune Rapidly Progressive Dementia)
GAD65 Autoantibody Test (Autoimmune Rapidly Progressive Dementia)
NMDA Receptor Autoantibody Test (Autoimmune Rapidly Progressive Dementia)
VGKC Autoantibody Test (Autoimmune Rapidly Progressive Dementia)
LGI1 Autoantibody Test (Autoimmune Rapidly Progressive Dementia)
CASPR2 Autoantibody Test (Autoimmune Rapidly Progressive Dementia)
Preferred Specimen
2 mL serum
Minimum Volume
0.5 mL
Instructions
Serum must be separated from cells within 48 hours of collection.
Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.
Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 72 hours
Refrigerated: 28 days
Frozen: 28 days
Refrigerated: 28 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Grossly icteric • Turbid • Bacterial contamination
Methodology
Immunofluorescence Assay • Radioimmunoassay • Enzyme-Linked Immunosorbent Assay (ELISA) • Automated Nanoliter Scale Immunoassay
FDA Status
This test was developed and its analytical performance characteristics have been determined by Athena Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon, Thurs; Report available: 7-10 days
Reference Range
See Laboratory Report
Clinical Significance
Anti-Hu, anti-CV2, anti-Ma, anti-Ta antibodies, anti-voltage gated potassium channels (VGKC), anti-Amphiphysin, anti-GAD65, anti-NMDA receptor (NR1), anti-LGI1, and anti-CASPR2 antibodies are found in patients with rapidly progressive dementias (RPDs). RPDs are neurological disorders that develop over weeks to months, or rarely acutely over days. This semi-quantitative assay may be useful in monitoring therapeutic responses in select cases.
