ADmark® Alzheimer's Evaluation

Test Code

93798

CPT Codes
81401, 83520 (x3)<br /> Limited Access Code

Physician Attestation of Informed Consent

This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.

Includes

Phospho-Tau, Total-Tau, Ab42, ApoE

Athena does not perform ApoE testing for individuals under the age of 18. Patients must be symptomatic for Dementia

Preferred Specimen

8 mL whole blood collected in EDTA (lavender-top) tube(s), and 2 mL CSF collected in a polypropylene tube

Minimum Volume

6 mL whole blood • 0.5 mL CSF

Instructions

Informed Consent Required

Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.

Whole blood-DNA yields and quality are better in fresh specimens. However, when necessary, most genetic tests are successful from DNA purified from whole blood that is several days old.

CSF-Tubes other than polypropylene are not acceptable

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Whole blood
Room temperature: 10 days
Refrigerated: 10 days
Frozen: Call lab

CSF
Room temperature: 72 hours
Refrigerated: 21 days
Frozen: 4 months

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

CSF samples that arrive in non-polypropylene tubes; CSF specimens with cell count > 500 erythrocytes/mm3

Methodology
Restriction Fragment Length Polymorphism, Enzyme-Linked Immunosorbent Assay

FDA Status
This test was developed and its analytical performance characteristics have been determined by Athena Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon, Wed; Report available: 14-21 days

Reference Range

Report correlates levels of markers of Phosphorylated-Tau, Total-Tau, and Ab42; Presence of ApoE2, E3, E4 alleles is reported

Clinical Significance

Detection of ApoE2, E3, E4 alleles and levels of Phosphorylated-Tau protein, Total-Tau protein, and AB42.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.