Frontotemporal Dementia (FTD) Evaluation

Test Code

92818

CPT Codes
81406 (x2), 81479<br /> Limited Access Code

Physician Attestation of Informed Consent

This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.

Includes

GRN DNA Sequencing, MAPT DNA Sequencing, C9orf72 DNA Sequencing

Preferred Specimen

8 mL whole blood collected in EDTA (lavender-top) tube(s)

Minimum Volume

6 mL

Instructions

Informed consent required.

Immediate shipping is recommended to optimize DNA quality and quantity. Ship room temperature, avoid freezing.

Specimen stability: DNA yields and quality are better in fresh specimens. However, when necessary, most genetic tests are successful from DNA purified from whole blood that is several days old.

Higher blood volumes ensure adequate DNA quantity, which varies with WBC, specimen condition, and need for confirmatory testing.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 10 days
Refrigerated: 10 days
Frozen: Unacceptable

Methodology
Next Generation Sequencing, Repeat Expansion Detection by Polymerase Chain Reaction

FDA Status
This test was developed and its analytical performance characteristics have been determined by Athena Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Varies; Report available: 21-28 days

Reference Range

No sequencing variants detected for MAPT and GRN genes.

For C9ORF72: Normal < 20 repeats

Clinical Significance

Detects expansions in the C9ORF72 gene. Detects mutations in the MAPT and GRN genes associated with frontotemporal dementia.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.