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GCK (MODY2) DNA Sequencing and Deletion Test

Test Code
92345


CPT Codes
81406, 81479<br><strong>CPT coding may differ dependent on payer rules which may impact prior authorization testing.</strong><br><strong>Please direct any questions regarding CPT coding to the payer being billed.</strong><br>Limited Access Code

Preferred Specimen
8 mL whole blood collected in two EDTA (lavender-top) tubes
Pediatric volume (0-3 years): 2 mL whole blood


Minimum Volume
6 mL • Pediatric: 1 mL


Instructions
⁠⁠⁠⁠⁠⁠⁠Higher blood volumes ensure adequate DNA quantity, which varies with WBC, specimen condition, and need for confirmatory testing. Patients, 0-3 years have higher WBC, yielding more DNA per mL of blood.


Transport Temperature
Room temperature


Specimen Stability
Room temperature: 10 days
Refrigerated: 10 days
Frozen: Unacceptable


Methodology
Sanger Sequencing • Multiplex Ligation-dependent Probe Amplification

Setup Schedule
Set up: As needed; Report available: 14-28 days


Reference Range
No sequence variation or deletion detected


Clinical Significance

Detects deletions and mutations in the GCK gene

Typical Presentation: Non-ketotic hyperglycemia in non-obese individuals of any age

Indications for testing: Non-ketotic insulin-sensitive hyperglycemia in individuals of any age; Family history of mutations in GCK





The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.