Tech-only, Plasma Cell Neoplasia Follow-up Panel

Test Code

91349

CPT Codes
88184, 88185 (x6)* This test code is for non-New York patient testing. For New York patient testing, use test code 38191. Client Restricted Code

Includes

Includes antibodies directed against CD20, CD38, CD45, CD56, CD138 and cytoplasmic kappa and lambda light chains.

Additional markers may be performed based on the pathologist review. These markers will be performed at an additional charge (CPT code(s): 88185 for each additional marker)

Preferred Specimen

Whole blood: 5 mL collected in a sodium heparin (green- top) tube, ACD-A (yellow-top) tube, or EDTA (lavender-top) tube or

Bone marrow: 4 mL collected in a sodium heparin (green-top) tube, ACD-A (yellow-top) tube, or EDTA (lavender-top) tube or

Tissue or body fluids: Any type is acceptable

Minimum Volume

3 mL whole blood • 1 mL bone marrow

Other Acceptable Specimens

Bone marrow: Pediatric heparin tube

Instructions

Whole blood and bone marrow:
The tube must be kept at room temperature and shipped to the lab immediately.

Tissue:
Any tissue type is acceptable. Tissue size is dependent upon leukocyte cellularity. Ship tissue in a sterile plastic container with RPMI 1640 enriched with FBS (10% FBS RPMI). Absolutely no fixative should be added. Refrigerate and ship immediately.

Body fluids:
Any body fluid is acceptable. Sample size is dependent upon cellularity of the sample. Place fluid in sterile plastic container. Absolutely no fixative should be added. Refrigerate and ship immediately.

Do not freeze. Send specimen to testing lab for viability determination. Do not reject.

Note: Additional markers may be performed based on the pathologist review. These markers will be performed at an additional charge. Any request for additional marker(s) must be communicated to laboratory within 48 hours of submitting sample and will delay results. A clinical indication and specimen source are required with each specimen. If possible, submit CBC results with differential. Because of the critical nature of these specimens, the laboratory will attempt to process all specimens received, regardless of age of specimen. Specimens received frozen or in fixative will be rejected.

Transport Temperature

Whole blood and bone marrow: Room temperature
Tissue and body fluids: Refrigerated (cold packs)

Specimen Stability

Whole blood or bone marrow
Room temperature: 72 hours
Refrigerated: Unacceptable
Frozen: Unacceptable

Tissue or body fluid
Room temperature: 72 hours
Refrigerated: 72 hours
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

See instructions

Methodology
Flow Cytometry (FC)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon-Sat; Report available: 1 day

Reference Range

See Laboratory Report

Clinical Significance

Technical-only flow cytometry services utilizing a 7-marker panel for evaluation of tissues, fluids, blood or bone marrow to evaluate for the presence of a known plasma cell neoplasm. If lymphoma, leukemia, MDS or other myeloid disorders are in the diagnostic differential, please use test code 91346- Tech-only, Leukemia/Lymphoma Evaluation instead.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.