CEBPA Mutation Analysis, Extracted DNA

Test Code

90813

CPT Codes
81218<br /> Restricted Client Code

Preferred Specimen

0.03 mL extracted DNA

Instructions

DNA is to be shipped frozen. Do not thaw. Minimum and absolute minimum volume is 0.03 mL.
Ship DNA immediately after extraction is performed. DNA must remain frozen until testing.

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: See Instructions

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received room temperature • Received refrigerated

Methodology
Next Generation Sequencing

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Tues, Thurs, Sat; Report available: 3 days

Reference Range

CEBPA Mutation

Not detected

Clinical Significance

Accurate testing for CEBPA mutations is important for identification of the prognostically significant AML subtype, especially CN-AML. AML with mutated CEBPA is a provisional disease entity in the 2008 World Health Organization classification of leukemias. CEBPA constitutes a key prognostic AML panel together with FLT-3 and NPM1.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.