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Chromosome Analysis, Mosaicism, Tissue
Test Code39937
CPT Codes
88233, 88262, 88285<br>Limited Access Code
Preferred Specimen
5x5 mm tissue collected in a sterile container in Hanks' Ringer's solution or culture medium with antibiotics
Minimum Volume
2x3 mm
Instructions
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Patient's age, gestational age, and indication(s) for testing are necessary; please submit completed cytogenetics requisition form with information. POC specimens contain tissue of both maternal and fetal origin. In the laboratory, the submitted specimen is grossly dissected to determine if there is fetal tissue available for culture. If no fetal tissue is identified, the client will be notified, and the test canceled and replaced with a Cytogenetics Communication. If tissue culture for the specimen is unsuccessful, due to no growth or contamination, the test will be canceled and replaced by a Prenatal Specimen Culture code.
Signed informed consent is a requirement. POC transport media and handling instructions available upon request.
Special study with additional cells counted and billed may be added due to concurrent testing results. This test may be replaced by other Bill Codes, if the complete study cannot be performed, or if the specimen does not yield mitotically active cells for analysis: Prenatal Specimen Culture; or Cytogenetics Communication (if a communication is required).
Patient's age, gestational age, and indication(s) for testing are necessary; please submit completed cytogenetics requisition form with information. POC specimens contain tissue of both maternal and fetal origin. In the laboratory, the submitted specimen is grossly dissected to determine if there is fetal tissue available for culture. If no fetal tissue is identified, the client will be notified, and the test canceled and replaced with a Cytogenetics Communication. If tissue culture for the specimen is unsuccessful, due to no growth or contamination, the test will be canceled and replaced by a Prenatal Specimen Culture code.
Signed informed consent is a requirement. POC transport media and handling instructions available upon request.
Special study with additional cells counted and billed may be added due to concurrent testing results. This test may be replaced by other Bill Codes, if the complete study cannot be performed, or if the specimen does not yield mitotically active cells for analysis: Prenatal Specimen Culture; or Cytogenetics Communication (if a communication is required).
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable
Refrigerated: Acceptable
Frozen: Unacceptable
Methodology
Microscopy • Karyotype • Tissue Culture
Setup Schedule
Set up: Daily; Report available: 15 days
Reference Range
Interpretive report
Clinical Significance
Autosomal or Sex Chromosome Mosaicism not detected in lymphocytes may be determined in fibroblasts obtained from a tissue biopsy. Cells from organ biopsies obtained postmortem may still be suitable for chromosome analysis when the patient's blood is of questionable viability. Fetal tissues or extra embryonic membranes are frequently used to diagnose fetal chromosome abnormalities that are associated with approximately one-half of all first trimester spontaneous abortions.
