Chromosome Analysis, Mosaicism, POC, Tissue

Test Code

39937

CPT Codes
88230, 88263<br>Limited Access Code

Includes

Please note: If no fetal tissue is identified, the test will be canceled and replaced with a Cytogenetics Communication. If tissue
culture for the specimen is unsuccessful, due to no growth or contamination, the test will be canceled and replaced by a
Prenatal Specimen Culture code.

Special study with additional cells counted and billed may be added due to concurrent testing results. This test may be
replaced with Prenatal Specimen Culture or Cytogenetics Communication, if the complete study cannot be performed, or if
the specimen does not yield mitotically active cells for analysis.

Preferred Specimen

5x5 mm tissue collected in a sterile container in Hanks', Ringer's solution or culture medium with antibiotics

Minimum Volume

2x3 mm

Other Acceptable Specimens

5x5 mm fetal tissue in saline solution submitted in a sterile leak-proof container • Cultured cells collected in two T-25 flasks

Instructions

Signed informed consent is a requirement. POC transport media and handling instructions available upon request.

Fetal tissue sample minimum of 2x3 mm collected in a sterile container with Hanks', Ringer's solution, culture medium with antibiotics, or saline solution. Transport media should be refrigerated before use, but can be shipped at room temperature.

Transport Temperature

Room temperature

Specimen Stability

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Methodology
Microscopy • Karyotype • Tissue Culture

Setup Schedule

Set up: Daily; Report available: 15 days

Reference Range

See Laboratory Report

Clinical Significance

Autosomal or Sex Chromosome Mosaicism not detected in lymphocytes may be determined in fibroblasts obtained from a tissue biopsy. Cells from organ biopsies obtained postmortem may still be suitable for chromosome analysis when the patient's blood is of questionable viability. Fetal tissues or extra embryonic membranes are frequently used to diagnose fetal chromosome abnormalities that are associated with approximately one-half of all first trimester spontaneous abortions.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.