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Chromosome Analysis, Mosaicism, CVS
Test Code39936
CPT Codes
88235, 88267, 88280, 88285<br>Limited Access Code
Preferred Specimen
40 mg chorionic villus sampling collected in CVS transport media
Minimum Volume
20 mg
Instructions
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Patient's age, gestational age, and indication(s) for testing are necessary; please submit completed cytogenetics requisition form with information. CVS specimens contain tissue of both maternal and fetal origin. In the laboratory, the submitted specimen is grossly dissected to determine if there is fetal tissue available for culture. If no fetal tissue is identified, the client will be notified, and the test canceled and replaced with a Cytogenetics Communication. If tissue culture for the specimen is unsuccessful, due to no growth or contamination, the test will be canceled and replaced by a Prenatal Specimen Culture code.
**Signed informed consent is a requirement. CVS transport media and handling instructions available upon request.
Special study with additional cells counted and billed may be added due to concurrent testing results. This test may be replaced by other Bill Codes, if the complete study cannot be performed, or if the specimen does not yield mitotically active cells for analysis: Prenatal Specimen Culture; or Cytogenetics Communication (if a communication is required).
Patient's age, gestational age, and indication(s) for testing are necessary; please submit completed cytogenetics requisition form with information. CVS specimens contain tissue of both maternal and fetal origin. In the laboratory, the submitted specimen is grossly dissected to determine if there is fetal tissue available for culture. If no fetal tissue is identified, the client will be notified, and the test canceled and replaced with a Cytogenetics Communication. If tissue culture for the specimen is unsuccessful, due to no growth or contamination, the test will be canceled and replaced by a Prenatal Specimen Culture code.
**Signed informed consent is a requirement. CVS transport media and handling instructions available upon request.
Special study with additional cells counted and billed may be added due to concurrent testing results. This test may be replaced by other Bill Codes, if the complete study cannot be performed, or if the specimen does not yield mitotically active cells for analysis: Prenatal Specimen Culture; or Cytogenetics Communication (if a communication is required).
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable
Refrigerated: Acceptable
Frozen: Unacceptable
Methodology
Culture • Microscopy • Karyotype
Setup Schedule
Set up: Daily; Report available: 8 days
Reference Range
Interpretive report
Clinical Significance
This test will detect chromosome abnormalities of the fetus including numerical, structural, and mosaic abnormalities. Chromosome analysis will also reveal fetal gender and sex chromosome abnormalities. Indications for prenatal chromosome analysis may include advanced maternal age, abnormal fetal ultrasound, abnormal maternal serum screen, abnormal cell-free DNA results, history of a previous child with a chromosome abnormality, or a parent who carries a balanced chromosomal rearrangement or has another chromosome abnormality.
