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Chromosome Analysis, Mosaicism, Amniotic Fluid
Test Code39935
CPT Codes
88235, 88269, 88280, 88285<br /> Limited Access Code
Preferred Specimen
30 mL fresh amniotic fluid submitted in sterile centrifuge tubes
Minimum Volume
10 mL
Instructions
Patient's age, gestational age, and indication(s) for testing are necessary; please submit completed cytogenetics requisition form with information. Do not split even if AFP requested. Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab).
**Signed informed consent is a requirement. Amniotic fluid kit and handling instruction available upon request.
Special study with additional cells counted and billed may be added due to concurrent testing results. This test may be replaced by other Bill Codes, if the complete study cannot be performed, or if the specimen does not yield mitotically active cells for analysis: Prenatal Specimen Culture; or Cytogenetics Communication (if a communication is required).
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
**Signed informed consent is a requirement. Amniotic fluid kit and handling instruction available upon request.
Special study with additional cells counted and billed may be added due to concurrent testing results. This test may be replaced by other Bill Codes, if the complete study cannot be performed, or if the specimen does not yield mitotically active cells for analysis: Prenatal Specimen Culture; or Cytogenetics Communication (if a communication is required).
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable
Refrigerated: Acceptable
Frozen: Unacceptable
Methodology
Microscopy • Culture • Karyotype
Setup Schedule
Set up: Daily; Report available: 9-12 days
Reference Range
Interpretive report
Clinical Significance
Chromosome Analysis, Amniotic Fluid - Testing determines chromosomal status of the fetus. Numerical and structural chromosomal abnormalities can be diagnosed. Sex and the presence of more than one cell line (mosaicism) can also be determined. Indications include diagnosis of chromosome abnormalities in fetuses of women who are of advanced maternal age; had a previous child with a chromosome abnormality; parental carrier of a balanced translocation, inversion or marker chromosome; parental mosaicism and follow-up for abnormal maternal serum alpha fetoprotein or maternal screening results.
