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MVista® Coccidioides IgG, IgM Antibody by EIA
Test Code39038
CPT Codes
86635 (x2)<br>Limited Access Code
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Other Acceptable Specimens
CSF collected in a sterile transport tube
Instructions
Serum: Collect serum specimens in serum separator or red top tube. Allow blood to clot for 30 minutes, then centrifuge. Pipette serum into a plastic screw cap vial.
Transport Container
Plastic screw-cap vial
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 14 days
Refrigerated: 14 days
Frozen: 14 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Any specimen types other than serum or cerebrospinal fluid (CSF)
Methodology
Semi-Quantitative Indirect Enzyme Immunoassay (EIA)
Setup Schedule
Set up: Mon, Thurs; Report available: 4 days
Reference Range
See Laboratory Report
Clinical Significance
IgM and IgG antibodies to Coccidioides antigen usually appear during the first month of infection, decline over the next 3-6 months but remain detectable for approximately 18-24 months in some cases with self-limited illnesses. Antibodies may persist in patients with chronic pulmonary complications or progressive extrapulmonary (disseminated) coccidioidomycosis. Antibodies may be falsely-negative in some progressive or chronic cases. Follow-up testing maybe considered at weeks 2-4 to determine if antibody levels are increasing especially in patients with low positive (10 EU-20 EU) or intermediate results.
Increase in antibody concentration would suggest recent infection. Antibodies may also be detected in healthy subjects who are asymptomatic as a result of sub-clinical infection within the last 18-36 months.
Increase in antibody concentration would suggest recent infection. Antibodies may also be detected in healthy subjects who are asymptomatic as a result of sub-clinical infection within the last 18-36 months.
