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MVista® Histoplasma IgG, IgM Antibody by EIA
Test Code39037
CPT Codes
86698 (x2)<br>Limited Access Code
Preferred Specimen
1 mL serum, or
1 mL CSF collected in a sterile transport tube
1 mL CSF collected in a sterile transport tube
Minimum Volume
0.5 mL
Instructions
Serum: Collect serum specimens in serum separator or red top tube. Allow blood to clot for 30 minutes, then centrifuge. Pipette serum into a plastic screw cap vial.
CSF: Sterile transport tube
Specimen Stability: Provide for each sample type if it differs (preferred and acceptable)
CSF: Sterile transport tube
Specimen Stability: Provide for each sample type if it differs (preferred and acceptable)
Transport Container
Plastic screw-cap vial
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 14 days
Refrigerated: 14 days
Frozen: 14 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
>14 days old • Any specimen types other than serum or CSF • For specimen submissions that do not meet this criteria, please call Customer Service
Methodology
Semi-Quantitative Indirect Enzyme Immunoassay (EIA)
Setup Schedule
Set up: Mon, Thurs; Report available: 4 days
Reference Range
See Laboratory Report
Clinical Significance
IgM and IgG antibodies to Histoplasma antigen usually appear during the first month of infection. The IgM antibody response in acute pulmonary histoplasmosis is detectable during the acute phase (roughly 3 weeks) and is shown to decline during the convalescent stage (at about 6 weeks); whereas, IgG levels remained relatively constant at 6 weeks. Follow-up testing may be considered 2-4 weeks after initial testing to determine if antibody levels are increasing, especially in patients with low positive (10 EU-20 EU) or intermediate results. Increase in IgG antibody or decrease in IgM concentration would suggest recent infection. Antibodies may persist for several years in patients with chronic pulmonary complications or progressive extrapulmonary (disseminated) histoplasmosis. Antibodies may be falsely-negative in some progressive or chronic cases, especially in immunocompromised patients. Antibodies may also be detected in healthy subjects who are asymptomatic as a result of sub-clinical infection within the last 18-36 months.
