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Chloride
Test Code38445
CPT Codes
82435<br>Limited Access Code
Preferred Specimen
1 mL serum collected in a serum separator tube (SST)
Minimum Volume
0.5 mL
Other Acceptable Specimens
Plasma collected in sodium or lithium heparin (green-top) tube, or plasma separator tube (PST)
Instructions
Centrifuge serum or plasma specimens within 1 hour of collection, transfer serum or plasma to a sterile, plastic, screw-capped vial(s), and ship at room temperature.
Transport Container
Sterile, plastic screw-capped vial
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days
Refrigerated: 7 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Anticoagulants other than heparin
Methodology
Ion Selective Electrode
Setup Schedule
Set up: Daily; Report available: Next day
Reference Range
98-110 mmol/L
Clinical Significance
Serum chloride is the major extracellular anion and counter-balances the major cation, sodium, maintaining electrical neutrality of the body fluids. Two-thirds of the total anion concentration in extracellular fluids is chloride and it is significantly involved in maintaining proper hydration and osmotic pressure. Movement of chloride ions across the red blood cell membrane is essential for the transport of bicarbonate ions in response to changing concentrations of carbon dioxide. Chloride measurements are used in the diagnosis and treatment of electrolyte and metabolic disorders, such as cystic fibrosis and diabetic acidosis.