FISH, MLL (11q23) Gene Rearrangement, Technical Component

Test Code

37886

CPT Codes
88271 (x2), 88275<br /> Tech Only Code

Preferred Specimen

3 mL bone marrow or 5 mL whole blood collected in a sodium heparin (green-top) tube

Minimum Volume

1 mL bone marrow • 3 mL whole blood

Other Acceptable Specimens

Bone marrow or whole blood collected in: sodium heparin (royal blue-top), or sodium heparin lead-free (tan-top) tube

Instructions

Other vacutainer tubes containing sodium heparin are acceptable.

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: See instructions
Refrigerated: See instructions
Frozen: See instructions

Methodology
Fluorescence in situ Hybridization

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Daily; Report available: 5 days

Reference Range

Interpretive report

Clinical Significance

This test is performed to detect the rearrangements of MLL (KMT2A; 11q23) gene by FISH (fluorescence in situ hybridization). MLL rearrangements have been observed in hematologic neoplasms of either lymphoid or myeloid origin.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.