FISH, Locus specific Probe (x3),TC

Test Code

37884

CPT Codes
88271 (x3), 88275 (x3)<br>Restricted Client Code - Tech Only Code

Includes

This test code is for ordering interphase fluorescence in situ hybridization (FISH) analysis of 100-300 cells using three probes. The locus for the probes must be identified with the order. Please contact performing laboratory for availability or probes.

If one or more FISH tests are ordered on a specimen without chromosome analysis, a tissue culture test code will be added at an additional charge.

Preferred Specimen

5 mL whole blood or 3 mL bone marrow collected in a sodium heparin (green-top) tube, or sodium heparin (royal blue-top) tube, or sodium heparin lead-free (tan-top) tube, or
5 mL amniotic fluid in sterile container, or
5 mg chorionic villus sample in culture media, or
5x5mm fresh tissue in culture transport media or sterile container with Hank's or Ringers solution, or
5x5mm fresh tissue in formalin-fixed paraffin-embedded tissue block

Minimum Volume

1 mL whole blood or bone marrow • 1 mL amniotic fluid • 5 mg chorionic villus • 5x5mm fresh tissue

Instructions

This test is performed in addition to G-banding chromosome analysis. Submit appropriate specimen as required for conventional cytogenetic analysis (amniotic fluid, whole blood, bone marrow, or tissue).

Clinical history/reason for referral is required with test order. Prior therapy and transplant history should be provided with test order.

3-5 mL whole blood or 1-3 mL bone marrow collected in a sodium heparin tube, 5 mL Amniotic fluid collected in sterile container, 5 mg CVS in culture media, 5 X 5 mm Fresh tissue in sterile container, formalin-fixed, paraffin-embedded tissue.

Specimen viability decreases during transit. Send specimen to testing lab for viability. Do not freeze. Do not reject.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: See instructions
Refrigerated: See instructions
Frozen: See instructions

Methodology
Fluorescence in situ Hybridization

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Daily; Report available: 5 days

Reference Range

Interpretive report

Clinical Significance

This FISH (fluorescence in situ hybridization) assay is performed using any combination of three probes.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.