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17-OHProgesterone-60 Min
Test Code37733
CPT Codes
83498<br /> Limited Access Code
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.5 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube, or sodium heparin (green-top) tube, or lithium heparin (green-top) tube, or EDTA (royal blue-top) tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 2 years
Refrigerated: 7 days
Frozen: 2 years
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Sun-Fri; Report available: 3-6 days
Reference Range
17-OHProgesterone-60 Min
Reference Ranges for 17-Hydroxyprogesterone
ACTH Stimulation-60 Minutes:
Adults:
Males and Females:
(Follicular Phase): 42-250 ng/dL
Pediatrics:
1-12 months: 85-465 ng/dL
1-5 years: 50-350 ng/dL
6-12 years: 75-220 ng/dL
Tanner Stages:
II-III Males: 69-310 ng/dL
II-III Females: 80-420 ng/dL
IV-V Males: 105-230 ng/dL
IV-V Females: 80-225 ng/dL
Includes data from J Clin Endocrinol Metab.
1991;73:674-686; J Clin Endo crinol Metab. 1989;
69:1133-1136; and J Clin Endocrinol Metab. 1994;
78:226-270
Reference Ranges for 17-Hydroxyprogesterone
ACTH Stimulation-60 Minutes:
Adults:
Males and Females:
(Follicular Phase): 42-250 ng/dL
Pediatrics:
1-12 months: 85-465 ng/dL
1-5 years: 50-350 ng/dL
6-12 years: 75-220 ng/dL
Tanner Stages:
II-III Males: 69-310 ng/dL
II-III Females: 80-420 ng/dL
IV-V Males: 105-230 ng/dL
IV-V Females: 80-225 ng/dL
Includes data from J Clin Endocrinol Metab.
1991;73:674-686; J Clin Endo crinol Metab. 1989;
69:1133-1136; and J Clin Endocrinol Metab. 1994;
78:226-270
Clinical Significance
17-hydroxyprogesterone is elevated in patients with congenital adrenal hyperplasia (CAH). CAH is a group of autosomal recessive diseases characterized by a deficiency of cortisol and an excess of ACTH concentration. 17-hydroxyprogesterone is also useful in monitoring cortisol replacement therapy and in evaluating infertility and adrenal and ovarian neoplasms.
