Prometheus® TPMT Genetics

Test Code

14851

CPT Codes
81401<br>Restricted Client Code

Preferred Specimen

5 mL whole blood collected in an EDTA (lavender-top) tube

Minimum Volume

2.5 mL

Instructions

Use normal phlebotomy procedure. Do not transfer to other containers. Specimen stability is crucial. Do not freeze specimens

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 24 hours
Refrigerated: 8 days
Frozen: Unacceptable

Methodology
Polymerase Chain Reaction

Setup Schedule

Set up: Mon-Fri; Report available: 5 days

Reference Range

See Laboratory Report

Clinical Significance

The test aids the physician in identifying patients at risk for acute toxicity to the thiopurine class of drugs before initiating therapy. It provides a genetic assessment, which determines a patient's ability to metabolize the thiopurine class of drugs. The activity of TPMT is genetically regulated. Studies have shown that one in 300 (0.3%) of individuals has low to absent TPMT enzyme activity (homozygous recessive), 11% have intermediate (heterozygous), and 89% have normal to high levels of activity (homozygous normal).

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.