Schwannomatosis/Multiple Schwannoma Panel (SCH-NG)

Test Code

11549

CPT Codes
81405, 81406, 81479<br>This test is not available for New York patient testing<br>Limited Access Code

Preferred Specimen

6 mL whole blood collected in an EDTA (lavender-top) tube

Minimum Volume

3 mL whole blood • 25 uL of 3 ug extracted DNA

Other Acceptable Specimens

Saliva collected in OGR-575 DNA Genotek (kits are provided upon request) • DNA (extracted from lymphocyte cells; a minimum volume of 25 uL at 3 ug; O.D. of 260:280nm > or = 1:8; must be extracted in a CLIA or equivalent certified lab) • Flash frozen tumor sent on dry ice • Fresh tumor or affected tissue biopsy, immersed in sterile culture media (PBS/RPMI)

Transport Temperature

Whole blood, saliva, DNA, fresh tumor: Room temperature
Flash frozen tumor: Frozen

Specimen Stability

Room temperature: Not established
Refrigerated: Not established
Frozen: Not established

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

No label (patients full name and date of collection) on the specimens • No referring physician's or genetic counselor's names and addresses • No billing information • DNA samples must be extracted in a CLIA or equivalent certified lab

Methodology
Next Generation Sequencing

FDA Status
This test was developed and its performance characteristics determined by the Medical Genomics Laboratory. It has not been cleared or approved by the FDA. The laboratory is regulated under CLIA as qualified to perform high-complexity testing. This test is use for clinical purposes. It should not be regarded as investigational or for research.

Setup Schedule

Set up: Varies; Report available: 30 working days

Reference Range

See Laboratory Report

Clinical Significance

Patients with multiple schwannomas with or without vestibular schwannomas. This testing approach is developed to diagnose mosaic NF2, classic NF2, Schwannomatosis, and mosaic schwannomatosis.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.