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Anti-MDA-5, NORMAL
Test Code11448
CPT Codes
83520<br>Limited Access Code
Preferred Specimen
1 mL serum collected in a red-top tube (no gel), or a gel barrier tube
Minimum Volume
0.3 mL
Instructions
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Transport Container
Transport tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 60 days
Refrigerated: 14 days
Frozen: 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Grossly hemolyzed • Bacterial contamination • Lipemic specimen • Icteric specimen • Non-serum specimen types
Methodology
Enzyme Linked Immunosorbent Immunoassay (ELISA)
Setup Schedule
Set up: Varies; Report available: 14-21 days
Reference Range
See Laboratory Report
Clinical Significance
Anti-MDA5 antibodies are present in 7-35% of adult DM. Clinical features consist of absent or mild muscle symptoms (CADM), rapidly progressive ILD, specific mucocutaneous features of skin ulcerations and papules, oral ulcerations, and arthritis.
