FISH, Prenatal Screen, Amniotic Fluid

Test Code

10393

CPT Codes
88271 (x5), 88274 (x2)<br>Limited Access Code

Preferred Specimen

20 mL amniotic fluid collected in a sterile, screw-cap container

Minimum Volume

5 mL

Instructions

Clinical history/reason for referral is required with test order.
Ship at room temperature. Specimen viability decreases during transit. Send specimen to testing lab for viability determination. DO NOT FREEZE. DO NOT REJECT.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable

Methodology
Fluorescence In Situ Hybridization

Setup Schedule

Set up: Daily; Report available: 24-48 hours from receipt of sample in laboratory

Reference Range

Interpretive report

Clinical Significance

This fluorescence in situ hybridization (FISH) prenatal screening test is used for numerical abnormalities of chromosomes X, Y, 13, 18, and 21 in amniotic fluid and chorionic villus samples. This test will not detect chromosomal rearrangements or numerical abnormalities that do not include the above chromosomes or regions of hybridization on the above chromosomes. Since this is a screening test, the results MUST be evaluated in conjunction with a standard chromosome study or a chromosomal microarray (CMA) study. Medical decisions should not be based solely on FISH screen results. The American College of Medical Genetics recommends that irreversible therapeutic action should not be taken based on the results of FISH analysis alone (Am. J. Hum. Genet. 53:526-527, 1993).

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.