Alpha-L-Iduronidase, Leukocytes

Test Code

10160

CPT Codes
82657<br>Restricted Client Code

Preferred Specimen

6 mL whole blood collected in an ACD solution B (yellow-top) tube

Minimum Volume

2 mL

Other Acceptable Specimens

Whole blood collected in: ACD solution A (yellow-top) tube or EDTA (lavender-top) tube

Instructions

For optimal isolation of leukocytes, it is recommended the specimen arrive refrigerated within 96 hours of collection to be stabilized. Collect specimen Monday through Thursday only and not the day before a holiday. Specimen should be collected and packaged as close to shipping time as possible.

Send specimen in original tube. Do not transfer blood to other containers.

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 6 days
Refrigerated: 6 days
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis

Methodology
Flow Injection Analysis-Tandem Mass Spectrometry (FIA-MS/MS)

FDA Status
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Setup Schedule

Set up: Varies; Report available: 5-10 days

Reference Range

> or =2.06 nmol/hour/mg protein

Clinical Significance

Diagnosis of mucopolysaccharidosis I, Hurler, Scheie, and Hurler-Scheie syndromes in leukocytes.

This test is not useful for determining carrier status.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.