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Cryptococcal Antigen Latex (CSF)
Test Code032251
CPT Codes
86403<br>Restricted Client Code
Includes
If Cryptococcal antigen screen is result is detected, equivocal, or indeterminate, then a reflex to titer will be performed at an additional charge (CPT code: 86406).
Preferred Specimen
2 mL serum collected in serum separator tube (SST)
Minimum Volume
0.5 mL
Instructions
Centrifuge serum specimens within 1 hour of collection. Transfer serum to clean, plastic, screw-capped vial(s). Refrigerate samples and transport on refrigerant coolant, or freeze samples and transport on dry ice to the laboratory.
Transport Container
Transport tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 72 hours
Frozen (-70ºC): 60 days (glass tubes unacceptable)
Refrigerated: 72 hours
Frozen (-70ºC): 60 days (glass tubes unacceptable)
Methodology
Latex Agglutination
Setup Schedule
Set up: Daily; Report available: Next day
Reference Range
See Laboratory Report
Clinical Significance
The encapsulated soil yeast, Cryptococcus neoformans, causes cryptococcosis. Pulmonary infection is acquired by inhalation of the organism and is usually subclinical in the immunocompetent host. Dissemination may occur in an immunocompromised patient, often to the meninges.