Chromosome Analysis and AFP with Reflex to AchE, Fetal Hgb, and Oligo-SNP

Test Code

93029

CPT Codes
82106, 88235, 88269, 88280<br>This test code is for non-New York patient testing. For New York patient testing, use test code 93131.

Includes

If Chromosomes Analysis, Amniotic Fluid is normal, then the Chromosomal Microarray, Prenatal, ClariSure® Oligo-SNP will be performed at an additional charge. (CPT code(s): 81229).
If AFP MoM is ≥2.0, then Acetylcholinesterase and Fetal Hemoglobin will be performed at an additional charge. (CPT code(s): 82664, 83033).

Preferred Specimen

30 mL fresh amniotic fluid collected in a sterile tube

Minimum Volume

10 mL

Instructions

Patient s age, gestational age, and indication(s) for testing are necessary; please submit completed cytogenetics requisition form with information. Do not split even if AFP requested. Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab).

Signed informed consent is a requirement. Amniotic fluid kit and handling instruction available upon request.

Note: This test may be replaced by other Bill Codes, if the complete study cannot be performed, or if the specimen does not yield mitotically active cells for analysis: Prenatal Specimen Culture; or Cytogenetics Communication (if a communication is required).

Do not reject. Specimen viability decreases during transit. Send specimen to testing lab for viability determination.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable

Methodology
Culture • Microscopy • Karyotype • Chemiluminescent • Gel Electrophoresis • Immunodiffusion • Oligo-SNP Array

Setup Schedule

Set up: Daily; Report available: 9-12 days (additional days for reflex if needed)

Reference Range

See Laboratory Report

Clinical Significance

Testing determines chromosomal status of the fetus. Numerical and structural chromosomal abnormalities can be diagnosed. Sex and the presence of more than one cell line (mosaicism) can also be determined. Indications include diagnosis of chromosome abnormalities in fetuses of women who are of advanced maternal age; had a previous child with a chromosome abnormality; parental carrier of a balanced translocation, inversion or marker chromosome; parental mosaicism and follow-up for abnormal maternal serum alpha fetoprotein or maternal screening results.
Chromosomal Microarray, Prenatal, ClariSure® Oligo-SNP - This assay may be useful for:
• Further investigation on fetuses with abnormal ultrasound findings indicating congenital malformation.
• Further definition of an imbalanced cytogenetic abnormality.
• Further investigation on equivocal cytogenetic findings.
• Attempt at characterization of supernumerary marker chromosome.
• Follow-up to a documented chromosome abnormality or genomic alteration in a sibling or a parent.
• Family history of a previous child with mental retardation and/or phenotypic abnormalities.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.