Benzodiazepines, Serum

Test Code

70071

CPT Codes
80346

Includes

Alprazolam, Alpha-Hydroxyalprazolam, Alpha-Hydroxytriazolam, Chlordiazepoxide, Clonazepam, Desalkylflurazepam, Diazepam, Lorazepam, Midazolam, Norchlordiazepoxide, Nordiazepam, Oxazepam, Temazepam, Triazolam

Preferred Specimen

2 mL serum collected in a red-top tube (no gel)

Minimum Volume

1 mL

Transport Temperature

Frozen

Specimen Stability

Room temperature: 24 hours
Refrigerated: 72 hours
Frozen: 14 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gel barrier/Serum Separator Tube

Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Tuesday, Thursday, Saturday Morning
Report available: 4 Days

Reference Range

Temazepam	50-1000 ng/mL
Oxazepam
Therapeutic	200-500 ng/mL
Potentially toxic	>2000 ng/mL
Chlordiazepoxide	100-3000 ng/mL
Norchlordiazepoxide	100-3000 ng/mL
Nordiazepam	100-1500 ng/mL
Alprazolam	10-50 ng/mL
Alpha-Hydroxyalprazolam	5-25 ng/mL
Alpha-Hydroxytriazolam	5-20 ng/mL
Clonazepam	30-60 mcg/L
Desalkylflurazepam	30-150 ng/mL
Diazepam	100-1500 ng/mL
Lorazepam	50-240 ng/mL
Midazolam	50-600 ng/mL
Triazolam	5-20 ng/mL

Clinical Significance

Benzodiazepines are widely used as anxiolytics, sedative- hypnotics, muscle relaxants, and anticonvulsants. Benzodiazepines include drugs such as diazepam Valium®, chlordiazepoxide Librium®, oxazepam Serax®, lorazepam Ativan®, alprazolam Xanax®, clonazepam Clonopin® and triazolam Halcion®. Many common benzodiazepines are detected in urine by their metabolites oxazepam and nordiazepam. Psychological and physiological addictions, misuse and abuse of benzodiazepines have been described.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.