Histoplasma Antibody, Complement Fixation, CSF

Test Code

5297

CPT Codes
86698 (x2)

Includes

Yeast Phase Antibody and Mycelial Phase Antibody

Preferred Specimen

1 mL CSF collected in a sterile, leak-proof container

Minimum Volume

0.5 mL

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly icteric

Methodology
Complement Fixation (CF)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Tues-Sat; Report available: 2-5 days

Reference Range

Yeast Phase Antibody	<1:1 titer
Mycelial Phase Antibody	<1:1 titer

Interpretive Criteria

<1:1	Antibody Not Detected
≥1:1	Antibody Detected

Clinical Significance

Central nervous system infection occurs in up to 25% of patients with subacute progressive disseminated histoplasmosis. Detection of antibodies in CSF can serve as a useful tool for identifying these patients.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.