Herpesvirus 7 Antibodies (IgG, IgM)

Test Code

10937

CPT Codes
86790 (x2)

Preferred Specimen

1 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.5 mL

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Grossly hemolyzed • Lipemic • Icteric samples

Methodology
Immunofluorescence Assay (IFA)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Thurs; Report available: 1-7 days

Reference Range

Herpesvirus 7 Ab (IgG)

<1:320 titer

Interpretive Criteria

<1:320	No Increase in HHV-7 IgG titer
1:320	Equivocal
>1:320	Increased HHV-7 IgG titer

Herpesvirus 7 Ab (IgM)

<1:20 titer

Interpretive Criteria

<1:20	Antibody Not Detected
≥1:20	Antibody Detected

Clinical Significance

Human Herpesvirus 7 (HHV-7), a close relative of HHV-6, is found in >85% of the population, with transmission occurring in early childhood. Like HHV-6, HHV-7 is a cause of exanthum subitum (roseola infantum). Due to the ubiquitous nature of HHV-7 infection, >80% of individuals in the general population exhibit HHV-7 IgG titers ≥1:20; however, only 5% of these individuals exhibit titers >1:320. Thus, HHV-7 IgG titers >1:320 are suggestive of recent HHV-7 infection. Detection of HHV-7 specific IgM is also indicative of recent infection.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.