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Post-Transplant, JC Virus DNA, Real-Time PCR, Plasma
Test Code18010
CPT Codes
87799
Preferred Specimen
1 mL plasma collected in an EDTA (lavender-top) tube
Minimum Volume
0.5 mL
Instructions
For Shipper collection please see detailed instructions in Test Resources
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 30 days
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Samples collected in sodium or lithium heparin
Methodology
Real-Time Polymerase Chain Reaction
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Daily; Report available: 1 day
Reference Range
JC Virus DNA, QN PCR | Not Detected (IU/mL) |
JC Virus DNA, QN PCR | Not Detected (Log IU/mL) |
Clinical Significance
JC Polyoma Virus is the cause of Progressive Multifocal Leukoencephalopathy (PML), a severe demyelinating disease of the central nervous system. PML is a particular concern for individuals infected with the human immunodeficiency virus. Quantification of JC virus DNA is based upon the real-time PCR amplification and detection of JCV genomic DNA. Reportable range is 50 to 50,000,000 IU/mL (1.70 to 7.70 Log IU/mL).