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Platelet Antibody Screen, Serum
Test Code11484
CPT Codes
86022 (x5)
Preferred Specimen
1.5 mL serum collected in a red-top tube (no gel)
Patient Preparation
Do not collect within 72 hours of a platelet transfusion. Transfused platelets will interfere with this assay.
Minimum Volume
0.5 mL
Instructions
Serum should be separated from red cells prior to shipping.
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 48 hours
Frozen: 1 year
Refrigerated: 48 hours
Frozen: 1 year
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Serum separator tube
Methodology
Solid Enzyme-Linked Immunosorbent Assay
Setup Schedule
Monday-Saturday Morning Report available: 2 Days
Reference Range
See Laboratory Report
Clinical Significance
Platelet antibodies may be allo- or autoantibodies and may be directed to a wide range of antigenic "targets" carried on platelet cytoplasmic membranes. Serum platelet antibody test is optimized to identify the presence of platelet alloantibodies in the patient.
Platelet alloantibodies are involved in several clinical situations such as:
-Immune mediated refractoriness to platelet transfusions usually due to antibodies to HLA class I and sometimes to antibodies specific to platelet antigens.
-Neonatal alloimmune thrombocytopenia (NAIT)
-Posttransfusion purpura (PTP), which are usually associated with platelet-specific antibodies
This test is not recommended for the diagnosis of immune thrombocytopenia (ITP) or autoimmune thrombocytopenia. Tests that are optimized to detect antibodies bound to the platelets will be useful in these situations; cell-bound platelet antibody (Direct) test is strongly recommended instead (CBPAN / Cell Bound Platelet Auto-Antibody Screen, Blood).
Platelet alloantibodies are involved in several clinical situations such as:
-Immune mediated refractoriness to platelet transfusions usually due to antibodies to HLA class I and sometimes to antibodies specific to platelet antigens.
-Neonatal alloimmune thrombocytopenia (NAIT)
-Posttransfusion purpura (PTP), which are usually associated with platelet-specific antibodies
This test is not recommended for the diagnosis of immune thrombocytopenia (ITP) or autoimmune thrombocytopenia. Tests that are optimized to detect antibodies bound to the platelets will be useful in these situations; cell-bound platelet antibody (Direct) test is strongly recommended instead (CBPAN / Cell Bound Platelet Auto-Antibody Screen, Blood).
