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17-Hydroxyprogesterone Response to ACTH Stimulation
Test Code17682
CPT Codes
83498 (x2)
Includes
17-Hydroxyprogesterone, Baseline
17-Hydroxyprogesterone, 60 Minutes
17-Hydroxyprogesterone, 60 Minutes
Preferred Specimen
Baseline Serum: 1 mL serum collected in a red-top tube (no gel), and
2nd Serum: 1 mL serum collected in a red-top tube (no gel)
2nd Serum: 1 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.5 mL (each specimen)
Other Acceptable Specimens
Baseline Plasma: 1 mL plasma collected in an EDTA (lavender-top) tube, or EDTA (royal blue-top) tube, or sodium or lithium heparin (green-top) tube, and
2nd Plasma: 1 mL plasma collected in an EDTA (lavender-top) tube, or EDTA (royal blue-top) tube, or sodium or lithium heparin (green-top) tube
2nd Plasma: 1 mL plasma collected in an EDTA (lavender-top) tube, or EDTA (royal blue-top) tube, or sodium or lithium heparin (green-top) tube
Instructions
Draw baseline specimen. Draw another specimen 60 minutes after stimulation.
Serum separator tubes (SST) are unacceptable. Draw blood in a red-top tube (no gel). Separate serum after clotting. Ship serum refrigerated or frozen. Do not submit glass tubes.
Note: Cortrosyn (cosyntropin) not supplied by the laboratory.
This test cannot be collected at a Patient Service Center.
Serum separator tubes (SST) are unacceptable. Draw blood in a red-top tube (no gel). Separate serum after clotting. Ship serum refrigerated or frozen. Do not submit glass tubes.
Note: Cortrosyn (cosyntropin) not supplied by the laboratory.
This test cannot be collected at a Patient Service Center.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 2 years
Refrigerated: 7 days
Frozen: 2 years
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tubes (SST)
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Monday-Friday, Sunday Night
Report available: 5 Days
Report available: 5 Days
Reference Range
See Laboratory Report
Clinical Significance
17-hydroxyprogesterone is elevated in patients with congenital adrenal hyperplasia (CAH). CAH is a group of autosomal recessive diseases characterized by a deficiency of cortisol and an excess of ACTH concentration. 17-hydroxyprogesterone is also useful in monitoring cortisol replacement therapy and in evaluating infertility and adrenal and ovarian neoplasms.
