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Substance P
Test Code92105
CPT Codes
83520
Preferred Specimen
5 mL frozen serum collected in a serum separator tube (SST®)
Minimum Volume
1 mL
Instructions
Collect blood in SST® tube. Allow to clot for 30 minutes at room temperature. Centrifuge sample at 1000 x G for 15 minutes. Separate serum into a transfer tube as soon as possible. Freeze at -20° C immediately.
Transport Container
Plastic, leak-proof transfer tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 28 days
Refrigerated: Unacceptable
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Specimens received unfrozen • Refrigerated or ambient • Specimens outside of listed stability • Plasma
Methodology
Enzyme Immunoassay (EIA)
Setup Schedule
Set up: Mon (twice a month); Report available: 21 days
Reference Range
<1700 pg/mL
Clinical Significance
Substance P is a neuropeptide present in the central and peripheral nervous system. Substance P is a neurotransmitter released in response to pain and other noxious stimuli. Substance P is a neuropeptide of the tachykinin class that also includes neurokinin. Substance P is found in the brain, spinal cored, and peripheral tissues and is released from nerve endings in response to stimuli. Increased substance P levels can occur in neurogenic inflammation and physiological stress and may be associated with cardinoid or neuroendocrine tumors.