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Drug Monitoring, Methadone Metabolite, with Confirmation, Urine
Test Code39379
CPT Codes
80307
Includes
If you require medMATCH for this order code, you must also order code 39158 - Prescribed Drugs, medMATCH®. If 39158 is ordered, all Drug Monitoring order codes will be treated as medMATCH.
If this test code is not ordered with 39158, all medMATCH result codes will be DNR’d.
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Initial screen of the Methadone Metabolite drug class. If screen is positive, a confirmation will be performed at an additional charge (CPT code(s): 80358; HCPCS: G0480).
Confirmation includes the following analytes: EDDP, Methadone
If this test code is not ordered with 39158, all medMATCH result codes will be DNR’d.
.
Initial screen of the Methadone Metabolite drug class. If screen is positive, a confirmation will be performed at an additional charge (CPT code(s): 80358; HCPCS: G0480).
Confirmation includes the following analytes: EDDP, Methadone
Preferred Specimen
20 mL random urine collected in a clinical drug test transport vial
Minimum Volume
7 mL
Other Acceptable Specimens
Random urine collected in a sterile, leak-proof urine container
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 5 days
Refrigerated: 7 days
Frozen: 30 days
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Preserved samples
Methodology
Screen: Immunoassay (IA) • Confirmation: Mass Spectrometry (MS)
Setup Schedule
Monday-Sunday Evening
Report available: 3 Days
Report available: 3 Days
Reference Range
| Methadone Metabolite | <100 ng/mL |
| EDDP | <100 ng/mL |
| Methadone | <100 ng/mL |
Clinical Significance
Methadone is prescribed to patients for the alleviation of opioid addiction withdrawal symptoms and analgesic purposes. The test is a screening assay using a homogeneous enzyme immunoassay method of analysis. Presumptive positive screening tests are reflexed to a more specific and sensitive liquid chromatography mass spectroscopy (LC/MS/MS) confirmation test. Therapeutic urine drug monitoring of methadone and its metabolite EDDP is important for ensuring compliance to treatment strategies, as well as ensuring non-diversion for illicit purposes strategies. Urine or oral fluid are the specimens of choice for routine monitoring of patients taking prescription drugs. Use of serum/plasma should be limited to anuretic patients, or where a patient's clinical appearance does not coincide with their prescribed medications. No single monitoring approach provides adequate information about the pattern or dose of patient drug use. Safest prescribing habits should include a combination of tools and laboratory test results to correctly detect drug use patterns. Quantitative values cannot be used to assess the drug dose, because the drug is extensively metabolized and excreted in the urine.
