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FISH, Multiple Myeloma, 1q21
Test Code91388
CPT Codes
88275, 88271 (x2)<br /> <strong>Please note:</strong> Test is restricted to bone marrow specimens for New York patient testing.
Preferred Specimen
3 mL bone marrow submitted in culture transport media
Minimum Volume
1 mL
Other Acceptable Specimens
Bone marrow collected in: sodium heparin (green-top), or sodium heparin lead-free (tan-top), or sodium heparin (royal blue-top) tube
Transport Temperature
Room temperature
Specimen Stability
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Methodology
Fluorescence in situ hybridization (FISH)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Daily; Report available: 6 days
Reference Range
See Laboratory Report
Clinical Significance
Chromosomal abnormalities are detected in 80-85% of myeloma patients. One or more extra copies of 1q21 has been associated with poor prognosis in patients with newly diagnosed myeloma, whether as a sole abnormality or in combination with other nonrandom abnormalities. Prognostic factors such as this are helpful to clinicians in determining therapy and predicting long-term survival.