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FISH, AML/MDS, -7/ Deletion 7q31
Test Code16671
CPT Codes
88271 (x2), 88275
Preferred Specimen
3 mL bone marrow or 5 mL whole blood collected in a sodium heparin (green-top) tube
Minimum Volume
1 mL bone marrow • 3 mL whole blood
Other Acceptable Specimens
Bone marrow or whole blood collected in: sodium heparin (royal blue-top) tube, or sodium heparin lead-free (tan-top) tube
Instructions
Clinical history/reason for referral is required with test order. Prior therapy and transplant history should be provided with test order.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Note: This test is performed in addition to routine hematologic cytogenetic analysis. 100-200 interphase nuclei are examined for loss of signal(s), consistent with deletion 7q or monosomy 7. These chromosome abnormalities are associated with myeloid disorders, including myelodysplastic syndrome, myeloproliferative disorders, and acute myelogenous leukemia. The test is useful for the evaluation of suboptimal specimens, complex karyotypes, specimens with low mitotic activity, or when a normal karyotype is obtained.
If results are not possible, the test order may be canceled and replaced with a Cytogenetics Communication.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Note: This test is performed in addition to routine hematologic cytogenetic analysis. 100-200 interphase nuclei are examined for loss of signal(s), consistent with deletion 7q or monosomy 7. These chromosome abnormalities are associated with myeloid disorders, including myelodysplastic syndrome, myeloproliferative disorders, and acute myelogenous leukemia. The test is useful for the evaluation of suboptimal specimens, complex karyotypes, specimens with low mitotic activity, or when a normal karyotype is obtained.
If results are not possible, the test order may be canceled and replaced with a Cytogenetics Communication.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: See instructions
Refrigerated: See instructions
Frozen: See instructions
Refrigerated: See instructions
Frozen: See instructions
Methodology
Fluorescence in situ Hybridization (FISH)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Monday-Sunday Morning
Report available: 5 Days
Report available: 5 Days
Reference Range
See Laboratory Report
